H-89

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Chemical Information

Product name：H-89	Purity：98% min
CAS NO：127243-85-0	Solubility：Soluble in DMSO
Molecular Formula：C₂₀H₂₀BrN₃O₂S	Package：Package according to customer requirements
Molecular Weight：446.361	Storage：Store at -20℃

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Remarks

H-89 is a specific adenylyl cyclase inhibitor (DDA) and a cyclic AMP-dependent protein kinase inhibitor. H-89 blocks the action of equine growth hormone on in vitro maturation of equine oocytes. H-89 decreases the gain of excitation-contraction coupling and attenuates calcium sparks in the absence of beta-adrenergic stimulation. H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A.

S6 Kinase Inhibitors Related Prodcuts:

BI-D1870; AT7867; H-89 2HCl; Staurosporine; Pluripotin; LY-2584702; AT13148; Bosutinib; PF-4708671

References

[1]. Chijiwa T, et al. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D

[2]. Blazev R, et al. Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres. J Muscle Res Cell Motil. 2001;22(3):277-86.