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GSK 2334470

GSK 2334470 1227911-45-6
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Chemical Information
Product name:GSK 2334470 Purity:98% min
CAS NO:1227911-45-6 Solubility:10 mM in DMSO
Molecular Formula:C25H34N8O Package:Package according to customer requirements
Molecular Weight:462.59 Storage:Store at -20℃
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GSK2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM), which does not suppress the activity of 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 500-fold higher concentrations. GSK2334470 also inhibited T-loop phosphorylation and activation of Akt. GSK2334470 will be a useful tool for delineating the roles of PDK1 in biological processes.
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