PS-48

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Chemical Information

Product name：PS-48	Purity：98% min
CAS NO：1180676-32-7	Solubility：DMSO: >20mg/mL
Molecular Formula：C₁₇H₁₅ClO₂	Package：Package according to customer requirements
Molecular Weight：286.753	Storage：Store at 2-8°C

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Remarks

PS-48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator.

Synonyms:

(2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid;

5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid;

Chemical Properties:

Melting point: 114-115℃

Boiling point: 444.1±24.0 °C(Predicted)

density: 1.225±0.06 g/cm3(Predicted)

pka: 4.55±0.10(Predicted)

form: powder

color: white to off-white

PDK Inhibitors Related Prodcuts:

BX795; PHT-427; GSK2334470; PS-210; OSU-03012 (AR-12)

References

1: Mordhorst BR, Murphy SL, Ross RM, Samuel MS, Salazar SR, Ji T, Behura SK, Wells KD, Green JA, Prather RS. Pharmacologic Reprogramming Designed to Induce a Warburg Effect in Porcine Fetal Fibroblasts Alters Gene Expression and Quantities of Metabolites from Conditioned Media Without Increased Cell Proliferation. Cell Reprogram. 2018 Feb;20(1):38-48. doi: 10.1089/cell.2017.0040. PubMed PMID: 29412741; PubMed Central PMCID: PMC5804098.

2: Mordhorst BR, Murphy SL, Ross RM, Benne JA, Samuel MS, Cecil RF, Redel BK, Spate LD, Murphy CN, Wells KD, Green JA, Prather RS. Pharmacologic treatment of donor cells induced to have a Warburg effect-like metabolism does not alter embryonic development in vitro or survival during early gestation when used in somatic cell nuclear transfer in pigs. Mol Reprod Dev. 2018 Apr;85(4):290-302. doi: 10.1002/mrd.22964. Epub 2018 Mar 5. PubMed PMID: 29392839; PubMed Central PMCID: PMC5903921.