Y-27632 dihydrochloride

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Chemical Information

Product name：Y-27632 dihydrochloride	Purity：98% min
CAS NO：129830-38-2	Solubility：DMSO : ≥ 32 mg/mL (99.92 mM)
Molecular Formula：C₁₄H₂₃Cl₂N₃O	Package：Package according to customer requirements.
Molecular Weight：320.258	Storage：Store at -20℃

Quality control

COA

Remarks

Y-27632 dihydrochloride is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 dihydrochloride induces apoptosis. Y-27632 dihydrochloride primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.

ROCK Inhibitors Related Products:

Y-27632; Fasudil HCl; GSK429286A; RKI-1447; Azaindole-1; Belumosudil (KD025); AT13148; Thiazovivin

References

[1]. Ishizaki T, et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83.

[2]. Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.Chin Med J (Engl). 2012 Sep;125(18):3332-5.

[3]. Inan S, et al. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. Br J Pharmacol. 2008 Sep;155(1):44-51.