GSK429286A

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Chemical Information

Product name：GSK429286A	Purity：98% min
CAS NO：864082-47-3	Solubility：DMSO: ≥ 51 mg/mL
Molecular Formula：C₂₁H₁₆F₄N₄O₂	Package：Package according to customer requirements
Molecular Weight：432.371	Storage：Store at -20℃

Quality control

COA

Remarks

GSK429286A is a selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.

ROCK Inhibitors Related Products:

Y-27632 dihydrochloride; Y-27632; Fasudil HCl; RKI-1447; Azaindole-1; Belumosudil (KD025); AT13148; Thiazovivin

References

[1]. Goodman KB et al Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50(1):6-9.

[2]. Nichols RJ et al Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424(1):47-60.