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ACY-1215 Ricolinostat

ACY-1215 Ricolinostat 1316214-52-4
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Chemical Information
Product name:ACY-1215 Ricolinostat Purity:98% min
CAS NO:1316214-52-4 Solubility:DMSO : ≥ 50 mg/mL (115.34 mM)
Molecular Formula:C24H27N5O3 Package:Package according to customer requirements
Molecular Weight:433.503 Storage:Store at -20℃
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Remarks

Rocilinostat, previously known as ACY-1215, is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.

 

 

 

HDAC Inhibitors Related Prodcuts:

Mocetinostat; Dacinostat; Belinostat; Tacedinaline; RoMidepsin; Givinostat; Vorinostat; Tubastatin A HCl; Entinostat; Panobinostat; Trichostatin A; Pracinostat; AR-42; WT161; ACY-738; Tasquinimod; Domatinostat; LMK-235; BRD3308

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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