LMK-235

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Chemical Information

Product name：LMK-235	Purity：98% min
CAS NO：1418033-25-6	Solubility：DMSO : ≥ 30 mg/mL (101.92 mM)
Molecular Formula：C₁₅H₂₂N₂O₄	Package：Package according to customer requirements.
Molecular Weight：294.346	Storage：Store at -20℃

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Remarks

LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. LMK-235 demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μ M respectively).

HDAC Inhibitors Related Prodcuts:

Mocetinostat; Dacinostat; Belinostat; Tacedinaline; RoMidepsin; Givinostat; Vorinostat; Tubastatin A HCl; Entinostat; Panobinostat; Trichostatin A; Pracinostat; AR-42; Ricolinostat; WT161; ACY-738; Tasquinimod; Domatinostat; BRD3308

References

[1]. Marek L, et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J Med Chem. 2013 Jan 24;56(2):427-36.

[2]. Li A, et al. HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer. Oncotarget. 2016 Jun 21;7(25):37966-37978.