Darifenacin hydrobromide

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Chemical Information

Product name：Darifenacin hydrobromide	Purity：98% min
CAS NO：133099-07-7	Solubility：DMSO : 33.33 mg/mL (65.68 mM)
Molecular Formula：C₂₈H₂₉BrN₂O₂	Package：Package according to customer requirements
Molecular Weight：505.446	Storage：Store at -20℃

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Remarks

Darifenacin, also known as UK-88525, is a medication used to treat urinary incontinence. Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. It thereby decreases the urgency to urinate.

Darifenacin hydrobromide (UK-88525 hydrobromide) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.

Properties:

Boiling Point: 614.3ºC at 760 mmHg

Melting Point: 228-230ºC

Flash Point: 325.3ºC

Vapor Pressure: 1.11E-16mmHg at 25°C

AChR Inhibitors Related Products:

Donepezil Hcl; (-)-Huperzine A; PNU-120596; Scopolamine hydrobromide; Rivastigmine Tartrate; Vinblastine sulfate; Tolterodine tartrate; Amfebutamone hydrochloride; Solifenacin; Solifenacin succinate; Trospium chloride; Pyridostigmine bromide; Varenicline; Revefenacin; Imidafenacin

References

[1]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.

[2]. Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638.

[3]. Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847.