PNU-120596

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Chemical Information

Product name：PNU-120596	Purity：98% min
CAS NO：501925-31-1	Solubility：DMSO : 50 mg/mL (160.40 mM; Need ultrasonic)
Molecular Formula：C₁₃H₁₄ClN₃O₄	Package：Package according to customer requirements
Molecular Weight：311.721	Storage：Store at -20℃

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Remarks

PNU-120596, also known as NSC 216666, is α7 nicotinic acetylcholine receptor positive allosteric modulator. PNU-120596 reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates.

Synonyms:

1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea;

1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea;

Properties:

Density: 1.403g/cm3

Boiling Point: 385ºC at 760 mmHg

Flash Point: 186.6ºC

Refractive Index: 1.625

AChR Inhibitors Related Products:

Donepezil Hcl; (-)-Huperzine A; Scopolamine hydrobromide; Rivastigmine Tartrate; Darifenacin hydrobromide; Vinblastine sulfate; Tolterodine tartrate; Amfebutamone hydrochloride; Solifenacin; Solifenacin succinate; Trospium chloride; Pyridostigmine bromide; Varenicline; Revefenacin; Imidafenacin

References

[1]. Hurst RS, et al. A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci, 2005, 25(17), 4396-4405.

[2]. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci USA, 2007, 104(19), 8059-8064.