Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).
Properties:
Density: 1.12g/cm3
Boiling Point: 579.7ºC at 760mmHg
Flash Point: 304.4ºC
Refractive Index: 1.602
Vapor Pressure: 1.96E-13mmHg at 25°C
AChR Inhibitors Related Products:
Donepezil Hcl; (-)-Huperzine A; PNU-120596; Scopolamine hydrobromide; Rivastigmine Tartrate; Darifenacin hydrobromide; Vinblastine sulfate; Tolterodine tartrate; Amfebutamone hydrochloride; Solifenacin; Solifenacin succinate; Trospium chloride; Pyridostigmine bromide; Varenicline; Revefenacin