Abacavir

Abacavir (ABC) is an antiretroviral medication used to prevent and treat HIV/AIDS. It is of the nucleoside analog reverse transcriptase inhibitor (NRTI) type. Viral strains that are resistant to zidovudine (AZT) or lamivudine (3TC) are generally, but not always, sensitive to abacavir. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. It is available under the trade name Ziagen and in the combination formulations abacavir/lamivudine/zidovudine, abacavir/dolutegravir/lamivudine, abacavir/lamivudine.

Properties:

Appearance & Physical State: white powder

Density: 1.7g/cm3

Boiling Point: 636ºC at 760 mmHg

Flash Point: 338.4ºC

Refractive Index: 1.864

Vapor Pressure: 4.77E-17mmHg at 25°C

Reverse Transcriptase Inhibitors Related Prodcuts:

Rilpivirine; Tenofovir alafenamide fumarate; Tenofovir alafenamide; Alovudine; Adefovir; Adefovir dipivoxil; Efavirenz; Lersivirine; Abacavir sulfate

[1]. Charneira C, et al. Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity. Chem Res Toxicol. 2011 Dec 19;24(12):2129-41.

[2]. Hervey PS, et al. Abacavir: a review of its clinical potential in patients with HIV infection. Drugs. 2000 Aug;60(2):447-79.