L-743726 Efavirenz

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Chemical Information

Product name：L-743726 Efavirenz	Purity：98.0% min
CAS NO：154598-52-4	Solubility：DMSO : ≥ 38 mg/mL (120.38 mM)
Molecular Formula：C₁₄H₉ClF₃NO₂	Package：Package according to customer requirements
Molecular Weight：315.675	Storage：Store at -20℃

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Remarks

Efavirenz is a non-nucleoside reverse transcriptase inhibitor, NNRTI. Efavirenz is highly specific and potent allosteric inhibitors of HIV-1 reverse transcriptase. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It is used as part of highly active antiretroviral therapy for the treatment of a human immunodeficiency virus type 1.

Properties:
Appearance & Physical State: white to slightly pink crystalline powder
Density: 1.53 g/cm3
Melting Point: 139-141ºC
Boiling Point: 340.6ºC at 760 mmHg
Flash Point: 159.8ºC
Refractive Index: 1.58
Vapor Pressure: 8.53E-05mmHg at 25°C

Reverse Transcriptase Inhibitors Related Prodcuts:

Rilpivirine; Tenofovir alafenamide fumarate; Tenofovir alafenamide; Alovudine; Adefovir; Adefovir dipivoxil; Abacavir; Lersivirine; Abacavir sulfate

References

[1]. Young SD, et al. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5.

[2]. Held DM, et al. Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication. J Biol Chem. 2006 Sep 1;281(35):25712-22.