UK-453061 Lersivirine

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Chemical Information

Product name：UK-453061 Lersivirine	Purity：98% min
CAS NO：473921-12-9	Solubility：DMSO : 50 mg/mL (161.11 mM)
Molecular Formula：C₁₇H₁₈N₄O₂	Package：Package according to customer requirements
Molecular Weight：310.350	Storage：Store at -20℃

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COA

Remarks

Lersivirine, also known as UK-453061, is a novel second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy. It binds reverse transcriptase in a distinct way leading to a unique resistance profile. In February 2013, ViiV Healthcare announced a stop of the development program investigating lersivirine.

Reverse Transcriptase Inhibitors Related Prodcuts:

Rilpivirine; Tenofovir alafenamide fumarate; Tenofovir alafenamide; Alovudine; Adefovir; Adefovir dipivoxil; Abacavir; Efavirenz; Abacavir sulfate

References

[1]. Mowbray CE, et al. Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60.

[2]. Davis J, et al. The effect of lersivirine, a next-generation NNRTI, on the pharmacokinetics of midazolam and oral contraceptives in healthy subjects. Eur J Clin Pharmacol. 2012 Nov;68(11):1567-72.