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Pimecrolimus 137071-32-0
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Chemical Information
Product name:Pimecrolimus Purity:98% min
CAS NO:137071-32-0 Solubility:DMSO: ≥ 32 mg/mL
Molecular Formula:C43H68ClNO11 Package:Package according to customer requirements
Molecular Weight:810.45 Storage:Store at -20℃
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Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis (eczema). It is currently available as a topical cream, once marketed by Novartis (however Galderma is promoting the compound in Canada since early 2007) under the trade name Elidel. Pimecrolimus is an ascomycin macrolactam derivative. It has been shown in vitro that pimecrolimus binds to macrophilin-12(also referred to as FKBP-12) and inhibits calcineurin. Thus pimecrolimus inhibits T-cell activation by inhibiting the synthesis and release of cytokines from T-cells. Pimecrolimus also prevents the release of inflammatory cytokines and mediators from mast cells.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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