Bestatin Ubenimex

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Chemical Information

Product name：Bestatin Ubenimex	Purity：98% min
CAS NO：58970-76-6	Solubility：DMSO : 6 mg/mL (19.46 mM)
Molecular Formula：C₁₆H₂₄N₂O₄	Package：Package according to customer requirements
Molecular Weight：308.3730	Storage：Store at -20℃

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Remarks

Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells.

Properties:

Appearance & Physical State: White crystalline powder

Density: 1.197 g/cm3

Boiling Point: 604.7ºC at 760 mmHg

Melting Point: 245ºC

Flash Point: 319.5ºC

Refractive Index: 1.557

Immunology & Inflammation related Inhibitors Related Prodcuts:

Pimecrolimus; Cyclosporin A; GI254023X; Bindarit; TAPI-1; Avadomide; Thymopentin; Pranlukast; Laquinimod; VGX-1027; Y-320; Imiquimod; Levamisole hydrochloride; Halcinonide; Sodium gualenate; Aceclofenac; Fenoprofen calcium; Pidotimod; Etofenamate; Tenoxicam

References

[1]. Hossain A, et al. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 Aug;149:100-6

[2]. Qian X, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2016 May-Jun;23(3):e680-9.