Bindarit

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Chemical Information

Product name：Bindarit	Purity：98% min
CAS NO：130641-38-2	Solubility：DMSO : ≥ 46 mg/mL (141.81 mM)
Molecular Formula：C₁₉H₂₀N₂O₃	Package：Package according to customer requirements
Molecular Weight：324.374	Storage：Store at -20℃

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Remarks

Bindarit is a MCP-1 (Monocyte Chemotactic Protein-1) Synthesis inhibitor. Bindarit protects against bone loss induced by chikungunya virus infection. Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching. Bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis. Bindarit prolongs survival and reduces renal damage in NZB/W lupus mice.

CCR Inhibitors Related Products:

Maraviroc; R243; Cenicriviroc; Vicriviroc Malate; PF-4136309; Vicriviroc

References

[1]. Zoja, C., et al., Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int, 1998. 53(3): p. 726-34.

[2]. Gazzaniga, S., et al., Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft. J Invest Dermatol, 2007. 127(8): p. 2031-41.