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Product :

R243

R243 688352-84-3
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Chemical Information
Product name:R243 Purity:98% min
CAS NO:688352-84-3 Solubility:DMSO:71 mg/mL
Molecular Formula:C21H27NO4 Package:Package according to customer requirements
Molecular Weight:357.443 Storage:-20 ℃
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Remarks

R243 is a potent and selective CCR8 antagonist. R243 inhibits CCL1/CCR8 interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects.

 

Synonyms:

6H-1,3-Dioxolo[4,5-g][1,3]benzoxazine, 7,8-dihydro-7-[2-(tricyclo[3.3.1.13,7]dec-1-yloxy)ethyl]-;

 


 

 

CCR Inhibitors Related Products:

Maraviroc; Bindarit; Cenicriviroc; Vicriviroc Malate; PF-4136309; Vicriviroc 

References
1: Berenguer J, Lagerweij T, Zhao XW, Dusoswa S, van der Stoop P, Westerman B, de Gooijer MC, Zoetemelk M, Zomer A, Crommentuijn MHW, Wedekind LE, López-López À, Giovanazzi A, Bruch-Oms M, van der Meulen-Muileman IH, Reijmers RM, van Kuppevelt TH, García-Vallejo JJ, van Kooyk Y, Tannous BA, Wesseling P, Koppers-Lalic D, Vandertop WP, Noske DP, van Beusechem VW, van Rheenen J, Pegtel DM, van Tellingen O, Wurdinger T. Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8. J Extracell Vesicles. 2018 Mar 13;7(1):1446660. doi: 10.1080/20013078.2018.1446660. eCollection 2018. PubMed PMID: 29696074; PubMed Central PMCID: PMC5912193.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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