Vicriviroc Malate

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Chemical Information

Product name：Vicriviroc Malate	Purity：98% min
CAS NO：541503-81-5	Solubility：DMSO : 50 mg/mL (76.96 mM)
Molecular Formula：C₃₂H₄₄F₃N₅O₇	Package：Package according to customer requirements
Molecular Weight：667.716	Storage：Store at -20℃

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Remarks

Vicriviroc, also known as SCH 417690 and SCH-D, is a potent, orally active and selective CCR5 entry inhibitor of HIV-1. Vicriviroc is effective at nanomolar concentrations, it can be administered once daily. Vicriviroc binds to a small hydrophobic pocket between the transmembrane helices near the extracellular surface of the CCR5 receptor. Binding to this pocket induces a conformational change of the extracellular segment of CCR5 and prevents binding of gp120 to the target cell, consequently preventing the virus from entering the target cell at all.

CCR Inhibitors Related Products:

R243; Maraviroc; Bindarit; Cenicriviroc; PF-4136309; Vicriviroc; MK-0812

References

[1]. Tagat JR, et al. Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist. J Med Chem. 2004 May 6;47(10):2405-8.

[2]. Strizki JM, et al. Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9.