MK-0812

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Chemical Information

Product name：MK-0812	Purity：98% min
CAS NO：624733-88-6	Solubility：Soluble in DMSO
Molecular Formula：C₂₄H₃₄F₃N₃O₃	Package：Package according to customer requirements
Molecular Weight：469.540	Storage：Store at -20℃

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Remarks

MK-0812 is a potent and selective CCR2 antagonist. Chemokine (C-C motif) receptor 2 (CCR2) is central for the migration of monocytes into inflamed tissues. The inhibition of CCR2 signaling represents a potential therapeutic approach for treatment of metastasis without affecting homeostatic functions.

CCR Inhibitors Related Products:

Vicriviroc Malate; R243; Maraviroc; Bindarit; Cenicriviroc; PF-4136309; Vicriviroc

References

[1]. Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.J Immunol Methods. 2010 Jan 31;352(1-2):101-10.

[2]. Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis.Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.