Vicriviroc, also known as SCH 417690 and SCH-D, is a potent, orally active and selective CCR5 entry inhibitor of HIV-1. Vicriviroc is effective at nanomolar concentrations, it can be administered once daily. Vicriviroc binds to a small hydrophobic pocket between the transmembrane helices near the extracellular surface of the CCR5 receptor. Binding to this pocket induces a conformational change of the extracellular segment of CCR5 and prevents binding of gp120 to the target cell, consequently preventing the virus from entering the target cell at all.
CCR Inhibitors Related Products:
Vicriviroc Malate; R243; Maraviroc; Bindarit; Cenicriviroc; PF-4136309; MK-0812