Cenicriviroc

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Chemical Information

Product name：Cenicriviroc	Purity：99.0% min
CAS NO：497223-25-3	Solubility：DMSO : ≥ 125 mg/mL (179.36 mM)
Molecular Formula：C₄₁H₅₂N₄O₄S	Package：Package according to customer requirements
Molecular Weight：696.941	Storage：Store at -20℃

Quality control

Remarks

Cenicriviroc, also known as TAK-652 and TBR-652, is an experimental drug candidate for the treatment of HIV infection. It is being developed by Takeda Pharmaceutical and Tobira Therapeutics. Cenicriviroc is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell. Inhibition of CCR2 may have an anti-inflammatory effect.

CCR Inhibitors Related Products:

Maraviroc; R243; Bindarit; Vicriviroc Malate; PF-4136309; Vicriviroc

References

[1]. Lefebvre E, et al. Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis. PLoS One. 2016 Jun 27;11(6):e0158156

[2]. Kuwata T, et al. Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies. Antimicrob Agents Chemother. 2015 Nov 2;60(1):437-5