Zolmitriptan is a member of the triptan class agents with anti-migraine property. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B expressed in intracranial arteries and 5_HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of the vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relief migraine headaches by inhibition pro-inflammatory neuropeptide release.
Properties:
Appearance & Physical State: White or kind of white powder
Density: 1.217 g/cm3
Boiling Point: 563.3ºC at 760 mmHg
Melting Point: 136-141ºC
Flash Point: 294.5ºC
Refractive Index: 1.619
Vapor Pressure: 1.03E-12mmHg at 25°C
5-HT Receptor Inhibitors Related Products:
RS-127445; WAY-100635 Maleate; WAY-100635 maleate salt; Vortioxetine; Vortioxetine hydrobromide; Blonanserin; Intepirdine; Sertraline HCl; Lamotrigine; Azasetron hydrochloride; Iloperidone; Lasmiditan