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Pamiparib 1446261-44-4
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Chemical Information
Product name:Pamiparib Purity:98.0% min
CAS NO:1446261-44-4 Solubility:DMSO : 62.5 mg/mL (209.51 mM)
Molecular Formula:C16H15FN4O Package:Package according to customer requirements.
Molecular Weight:298.315 Storage:Store at -20℃
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Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.




PARP Inhibitors Related Products:

Veliparib hcl; Olaparib; XAV-939; Rucaparib; Talazoparib; A-966492; PJ34 HCl; Niraparib; WIKI4; G007-LK; AZD2461; Saroglitazar; Veliparib

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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