Zoledronic acid hydrate

Zoledronic acid is a synthetic imidazole bisphosphonate analog of pyrophosphate with anti-bone-resorption activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover.

Synonyms:
Appearance & Physical State: White to off-white powder.
Boiling Point: 764ºC at 760 mmHg
Flash Point: 415.8ºC
Vapor Pressure: 1.53E-24mmHg at 25°C

Ras Inhibitors Related Products:

Lonafarnib; Kobe2602; Zoledronic acid; K-Ras-IN-1; Kobe0065; Deltarasin; Salirasib; K-Ras(G12C) inhibitor; Adagrasib

[1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6.

[2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8.