Kobe0065

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：Kobe0065	Purity：98% min
CAS NO：436133-68-5	Solubility：DMSO : ≥ 42.5 mg/mL (94.49 mM)
Molecular Formula：C₁₅H₁₁ClF₃N₅O₄S	Package：Package according to customer requirements
Molecular Weight：449.792	Storage：Store at -20℃

Quality control

Remarks

Kobe0065 is a small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Kobe0065 binds to Ras-GTP, blocking interactions with Raf kinase. Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. Kobe0065 also inhibits tumor growth in SW480 colon cancer cell xenografts.

Ras Inhibitors Related Products:

Lonafarnib; Kobe2602; Zoledronic acid; K-Ras-IN-1; Zoledronic acid hydrate; Deltarasin; Salirasib; K-Ras(G12C) inhibitor ; Adagrasib

References

[1]. Shima, Fumi, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proceedings of the National Academy of Sciences of the United States of America (2013), 110(20), 8182-8187,

[2]. Shima F, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23