ROC-325

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Chemical Information

Product name：ROC-325	Purity：99% min
CAS NO：1859141-26-6	Solubility：DMSO : 32 mg/mL (63.61 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₂₈H₂₇ClN₄OS	Package：Package according to customer requirements
Molecular Weight：503.05818	Storage：Store at -20℃

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Remarks

ROC-325 is an autophagy inhibitor. ROC-325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. ROC-325 antagonized RCC growth and survival in an ATG5/7-dependent manner, induced apoptosis, and exhibited favorable selectivity.

Autophagy Inhibitors Related Products:

SBI-0206965; PFK-015; GSK690693; DC661; IITZ-01; CA-5f

References

[1]. Carew JS, et al. Disruption of Autophagic Degradation with ROC-325 Antagonizes Renal Cell Carcinoma Pathogenesis. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879.