Canertinib dihydrochloride Canertinib HCl

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Chemical Information

Product name：Canertinib dihydrochloride Canertinib HCl	Purity：98% min
CAS NO：289499-45-2	Solubility：Soluble in DMSO, not in water
Molecular Formula：C₂₄H₂₇Cl₃FN₅O₃	Package：Package according to customer requirements
Molecular Weight：558.86	Storage：Store at -20℃

Quality control

Remarks

Canertinib dihydrochloride (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.

Properties:

Density: 1.355g/cm3

Boiling Point: 691ºC at 760mmHg

Flash Point: 371.7ºC

Refractive Index: 1.649

Vapor Pressure: 6.08E-19mmHg at 25°C

HER2 Inhibitors Related Products:

Poziotinib (HM781-36B); Mubritinib; Tucatinib; Canertinib; Lapatinib; Lapatinib ditosylate; Afatinib (BIBW2992); Afatinib (BIBW2992) Dimaleate; CUDC-101; Sapitinib

References

[1]. Smaill JB, et al. Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J Med Chem. 2000 Apr 6;43(7):1380-97.

[2]. Djerf Severinsson EA, et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414(3):563-8.