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Tucatinib Irbinitinib

Tucatinib Irbinitinib 937263-43-9
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Chemical Information
Product name:Tucatinib Irbinitinib Purity:98% min
CAS NO:937263-43-9 Solubility:DMSO : 50 mg/mL (104.05 mM)
Molecular Formula:C26H24N8O2 Package:Package according to customer requirements
Molecular Weight:480.521 Storage:-20ºC
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Remarks

Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

 

 

 

HER2 Inhibitors Related Products:

Poziotinib (HM781-36B); Mubritinib; Canertinib; Canertinib dihydrochloride; Lapatinib; Lapatinib ditosylate; Afatinib (BIBW2992); Afatinib (BIBW2992) Dimaleate; CUDC-101; TAK-285; Sapitinib

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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