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TAK-165 Mubritinib

TAK-165 Mubritinib 366017-09-6
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Chemical Information
Product name:TAK-165 Mubritinib Purity:98% min
CAS NO:366017-09-6 Solubility:10 mM in DMSO
Molecular Formula:C25H23F3N4O2 Package:Package according to customer requirements
Molecular Weight:468.471 Storage:Store at -20℃
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Remarks
Mubritinib, also known as TAK-165, is a protein kinase inhibitor which was under development by Takeda for the treatment of cancer. It completed phase I clinical trials (may be discontinued since 2008). Mubritinib(TAK 165) is a potent EGFR, HER2 and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 µM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5. Mubritinib(TAK 165) displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Mubritinib(TAK 165) exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo. 
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