CP 28720 Glipizide

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Chemical Information

Product name：CP 28720 Glipizide	Purity：99% min
CAS NO：29094-61-9	Solubility：DMSO : 50 mg/mL (112.22 mM)
Molecular Formula：C₂₁H₂₇N₅O₄S	Package：Package according to customer requirements
Molecular Weight：445.535	Storage：Store at -20℃

Quality control

Remarks

Glipizide is a short-acting, second-generation, blood-glucose-lowering agent belonging to the sulfonylurea class that increases the release of endogenous insulin from β-cells by blocking potassium channels. The drug-formulated version of Glipizide, marketed as Glucotrol or under generic label, is most commonly prescribed to lower blood sugar levels in type 2 diabetes. Glipizide is rapidly absorbed, has a very quick onset of action and a short half-life. This agent is extensively metabolized in the liver and the metabolites as well as the unchanged form are excreted in the urine.

Properties:
Appearance & Physical State: White or off-white crystalline powder
Density: 1.34 g/cm3
Melting Point: 208-209ºC
Refractive Index: 1.597

Potassium Channel Inhibitors Related Prodcuts:

Vonoprazan Fumarate; Gliclazide; Almitrine dimesylate; JNJ303; Dofetilide; Dronedarone HCl; Mitiglinide Calcium; Glyburide; ML213

References

[1]. Chowdary, K.P. and Y.S. Rao, Design and in vitro and in vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: a technical note. AAPS PharmSciTech, 2003. 4(3): p. E39.

[2]. Rao, N.G., et al., Suicide by combined insulin and glipizide overdose in a non-insulin dependent diabetes mellitus physician: a case report. Med Sci Law, 2006. 46(3): p. 263-9.