15-keto Travoprost

Synonyms: 15-keto Fluprostenol isopropyl ester

Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1,2 Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.3 The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.

Related Prodcuts:  (+)-Cloprostenol; Cloprostenol; Misoprostol; Carboprost; Tafluprost; Dinoprostone; Dinoprost; Trometamol; Alprostadil; Iloprost; Limaprost; Bimatoprost; Latanoprost; Lubiprostone; Travoprost; 15S-Travoprost; 5,6-trans Travoprost; Fluprostenol Travoprost acid

1. Sorbera, L.A. and Castañer, J. Travoprost. Drugs of the Future 25, 41-45 (2000).

2. Hellberg, M.R.,Sallee, V.L.,McLaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. Journal of Ocular Pharmacology and Therapeutics 17(5), 421-432 (2001).

3. Taniguchi, T.,Haque, M.S.R.,Sugiyama, K., et al. Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits. Journal of Ocular Pharmacology 12, 489-498 (1996).