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Fluprostenol Travoprost acid

Fluprostenol Travoprost acid 54276-17-4
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Chemical Information
Product name:Fluprostenol Travoprost acid Purity:98% min
CAS NO:54276-17-4 Solubility:Soluble in DMSO
Molecular Formula:C23H29F3O6 Package:Package according to customer requirements
Molecular Weight:458.468 Storage:Store at -20℃
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COA
Remarks

Fluprostenol, (+)-, is an analog of Prostaglandin F2α with potent FP receptor agonist activity.A metabolically stable analog of Prostaglandin F2α with potent FP receptor agonist activity. An impurity of Travoprost.

 

Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity. Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively. It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 μg/kg to terminate pregnancy. It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10?11 M.

 

Chemical Name:

[3H]-Travoprost acid

 

Synonyms:

(+)-FLUPROSTENOL;

Travoprost Acid;

Fluprostenol;

 

 

 

Related Prodcuts:  (+)-Cloprostenol; Cloprostenol; Misoprostol; Carboprost; Tafluprost; Dinoprostone; Dinoprost; Trometamol; Alprostadil; Iloprost; Limaprost; Bimatoprost; Latanoprost; Lubiprostone; 15-keto Travoprost; 15S-Travoprost; 5,6-trans Travoprost; Travoprost 

References

1: Baryla M, Kaczynski P, Goryszewska E, Riley SC, Waclawik A. Prostaglandin 
F(2α) stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8/SVneo. Placenta. 2019 Feb;77:19-29. doi: 
10.1016/j.placenta.2019.01.020. Epub 2019 Jan 24. PubMed PMID: 30827352.

2: Gao L, Gao R, Mao W, Liu B, Zhang S, Tahala D, Fu C, Shen Y, Wu J, Deng Y, Li 
Q, Cao J. PTGFR activation promotes the expression of PTGS-2 and growth factors 
via activation of the PKC signaling pathway in bovine endometrial epithelial cells. Anim Reprod Sci. 2018 Dec;199:30-39. doi:10.1016/j.anireprosci.2018.10.003. Epub 2018 Oct 14. PubMed PMID: 30340853.

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