Carboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition.
DNA Alkylator/Crosslinker Related Products:
Cisplatin; Oxaliplatin; Temozolomide; Streptozocin; cyclophosphamide hydrate; Carmustine; Pepstatin A; Lurbinectedin