Lurbinectedin (PM01183)

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：Lurbinectedin (PM01183)	Purity：98% min
CAS NO：497871-47-3	Solubility：DMSO : 20 mg/mL (25.48 mM; Need ultrasonic)
Molecular Formula：C₄₁H₄₄N₄O₁₀S	Package：Package according to customer requirements
Molecular Weight：784.874	Storage：Store at -20 ℃

Quality control

Remarks

Lurbinectedin, also known as PM01183, is a synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. DNA minor groove-binding agent PM01183 covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.

DNA Alkylator/Crosslinker Related Products:

Cisplatin; Oxaliplatin; Temozolomide; Streptozocin; cyclophosphamide hydrate; Carmustine; Pepstatin A; Carboplatin

References

[1]. Takahashi R, et al. Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary. PLoS One. 2016 Mar 17;11(3):e0151050.

[2]. Leal JF, et al. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Br J Pharmacol. 2010 Nov;161(5):1099-110.