MRS 2578

MRS-2578 is a selective antagonist of P2Y6 nucleotide receptors (IC50 values are 37 and 98 nM at human and rat P2Y6 receptors respectively). Activation of P2Y6 receptor amplifies mucosal adenosine triphosphate release underlying bladder overactivity in patients with benign prostatic hyperplasia. Therefore, selective P2Y6 receptor blockade as a novel therapeutic strategy is potentially useful to control persistent storage symptoms in obstructed patients.

Properties:

Appearance & Physical State: White solid

Density: 1.31g/cm3

Boiling Point: 652.7ºC at 760 mmHg

Flash Point: 348.5ºC

Refractive Index: 1.686

P2 Receptor Inhibitors Related Products:

Prasugrel; Prasugrel metabolite; Ticagrelor; A-740003; Clopidogrel sulfate; Ivermectin (MK-933); Minodronic acid; AF-353

[1]. Mamedova LK, et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol, 2004, 67(9), 1763-1770.

[2]. Riegel AK, et al. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood, 2011, 117(8), 2548-2555.