AF353 is a P2X3 receptor antagonist. Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system.
Chemical Name:
5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine
Properties:
Boiling point: 510.2±60.0 °C(Predicted)
density: 1.619±0.06 g/cm3(Predicted)
pka: 6.89±0.10(Predicted)
P2 Receptor Inhibitors Related Products:
Prasugrel; Prasugrel metabolite; MRS 2578; Ticagrelor; A-740003; Clopidogrel sulfate; Ivermectin (MK-933); Minodronic acid