Minodronic acid

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Chemical Information

Product name：Minodronic acid	Purity：98% min
CAS NO：180064-38-4	Solubility：DMSO : < 1 mg/mL; H2O : 5 mg/mL (15.52 mM)
Molecular Formula：C₉H₁₂N₂O₇P₂	Package：Package according to customer requirements
Molecular Weight：322.148	Storage：Store at -20℃

Quality control

COA

Remarks

Minodronic acid (YM529, ONO-5920) is a third-generation nitrogen-cotaining bisphosphonate that is used for the treatment of osteoporosis. Minodronic acid is an aminobisphosphonate that is a selective antagonist of purinergic P2X2/3 receptors involved in pain.

Properties:

density: 1.97±0.1 g/cm3(Predicted)

pka: 1.48±0.10(Predicted)

P2 Receptor Inhibitors Related Products:

Prasugrel; Prasugrel metabolite; MRS 2578; Ticagrelor; A-740003; Clopidogrel sulfate; Ivermectin (MK-933); AF-353

References

[1]. Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61.

[2]. Tanaka M, et al. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36(1):54-63.