AZD-6140 Ticagrelor

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Chemical Information

Product name：AZD-6140 Ticagrelor	Purity：98% min
CAS NO：274693-27-5	Solubility：DMSO : ≥ 50 mg/mL (95.68 mM)
Molecular Formula：C₂₃H₂₈F₂N₆O₄S	Package：Package according to customer requirements
Molecular Weight：522.568	Storage：Store at -20℃

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Remarks

Ticagrelor, also known as AZD-6140 and AR-C 126532XX, is a platelet aggregation inhibitor produced by AstraZeneca. The drug was approved in 2011. Ticagrelor is an antagonist of the P2Y12 receptor. Like the thienopyridines prasugrel, clopidogrel and ticlopidine, ticagrelor blocks adenosine diphosphate (ADP) receptors of subtype P2Y12. In contrast to the other antiplatelet drugs, ticagrelor has a binding site different from ADP, making it an allosteric antagonist, and the blockage is reversible. Moreover, the drug does not need hepatic activation, which might work better for patients with genetic variants regarding the enzyme CYP2C19.

P2 Receptor Inhibitors Related Products:

Prasugrel; Prasugrel metabolite; MRS 2578; Ticagrelor; A-740003; Clopidogrel sulfate; Ivermectin (MK-933); Minodronic acid; AF-353; Ticagrelor intermediate(376608-71-8; 274693-53-7; 376608-65-0)

References

1: Nylander S, Schulz R. Effects of P2Y12 receptor antagonists beyond platelet inhibition - comparison of ticagrelor with thienopyridines. Br J Pharmacol. 2016 Apr;173(7):1163-78. doi: 10.1111/bph.13429. Epub 2016 Feb 24. Review. PubMed PMID: 26758983.

2: Guimarães PO, Tricoci P. Ticagrelor, prasugrel, or clopidogrel in ST-segment elevation myocardial infarction: which one to choose? Expert Opin Pharmacother. 2015;16(13):1983-95. doi: 10.1517/14656566.2015.1074180. Epub 2015 Jul 29. Review. PubMed PMID: 26224244.