Lovastatin inhibits HMGCR, blocking the enzyme-catalyzed transformation of 3-hydroxy-3-methylglutaryl CoA into mevalonate. Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts cholesterol synthesis, leading to a reduction of circulating low-density lipoproteins. Lovastatin demonstrates arrest of the cell cycle at the G1 phase in bladder carcinoma T24 cells.
Properties:
Appearance & Physical State: White solid
Density: 1.12 g/cm3
Boiling Point: 559.2ºC at 760 mmHg
Melting Point: 175ºC
Flash Point: 185.3ºC
Refractive Index: 320 ° (C=0.5, CH3CN)
HMG-CoA Reductase Inhibitors Related Prodcuts:
Simvastatin; Rosuvastatin calcium; Pitavastatin Calcium; Simvastatin ammonium salt; Rosuvastatin; Rosuvastatin Sodium; Rosuvastatin ethyl ester; Pitavastatin; Pravastatin Sodium