Pravastatin Sodium is an antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
Properties:
Appearance & Physical State: White Crystalline Powder
Boiling Point: 634.5ºCat 760 mmHg
Melting Point: 154-160ºC
Flash Point: 213.2ºC
HMG-CoA Reductase Inhibitors Related Prodcuts:
Simvastatin; Rosuvastatin calcium; Lovastatin; Pitavastatin Calcium; Simvastatin ammonium salt; Rosuvastatin; Rosuvastatin Sodium; Rosuvastatin ethyl ester; Pitavastatin