Pitavastatin

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Chemical Information

Product name：Pitavastatin	Purity：98% min
CAS NO：147511-69-1	Solubility：Soluble in DMSO
Molecular Formula：C₂₅H₂₄FNO₄	Package：Package according to customer requirements
Molecular Weight：421.461	Storage：Store at -20℃

Quality control

Remarks

Pitavastatin (NK-104) is a potent HMG-CoA reductase inhibitor, Pitavastatin inhibited cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in a human liver cancer cell line (HepG2).

Properties:
Density: 1.352g/cm3
Boiling Point: 692ºC at 760mmHg
Refractive Index: 1.679
Vapor Pressure: 4.21E-20mmHg at 25°C

HMG-CoA Reductase Inhibitors Related Prodcuts:

Simvastatin; Rosuvastatin calcium; Lovastatin; Pitavastatin Calcium; Simvastatin ammonium salt; Rosuvastatin; Rosuvastatin Sodium; Rosuvastatin ethyl ester; Pravastatin Sodium

References

[1]. Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7(3):138-44.

[2]. Katsuki S, et al. Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes. Circulation. 2014 Feb 25;129(8):896-906.