AMG-208

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Chemical Information

Product name：AMG-208	Purity：98% min
CAS NO：1002304-34-8	Solubility：DMSO : 7.8 mg/mL (20.34 mM)
Molecular Formula：C₂₂H₁₇N₅O₂	Package：Package according to customer requirements
Molecular Weight：383.403	Storage：Store at -20℃

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Remarks

AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c-Met. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers.

Related Products:

MGCD-265 analog; BMS777607; JNJ-38877605; Tivantinib; AMG-458; NVP-BVU972; Golvatinib; SU11274; BMS-794833; PF-04217903; Crizotinib

References

[1]. Albrecht BK, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008, 51(10), 2879-2882.

[2]. Boezio AA, et al. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009, 19(22), 6307-6312.

[3]. Liu X, et al. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med. 2010,16(1), 37-45.