PF-04217903

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Chemical Information

Product name：PF-04217903	Purity：98% min
CAS NO：956905-27-4	Solubility：DMSO : 20 mg/mL (53.71 mM; Need ultrasonic)
Molecular Formula：C₁₉H₁₆N₈O	Package：Package according to customer requirements
Molecular Weight：372.383	Storage：Store at -20℃

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Remarks

PF-04217903 is a MET tyrosine kinase inhibitor, is also a n orally bioavailabe, small-molecule tyrosine kinase inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met.

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MGCD-265 analog; BMS777607; JNJ-38877605; Tivantinib; AMG-208; AMG-458; NVP-BVU972; Golvatinib; SU11274; BMS-794833; Crizotinib

References

[1]. Timofeevski SL, et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry, 2009, 48(23), 5339-5349.

[2]. Shojaei F, et al. HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors. Cancer Res, 2010, 70(24), 10090-10100.