NVP-BVU972

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Chemical Information

Product name：NVP-BVU972	Purity：98% min
CAS NO：1185763-69-2	Solubility：DMSO: ≥ 42 mg/mL
Molecular Formula：C₂₀H₁₆N₆	Package：Package according to customer requirements
Molecular Weight：340.381	Storage：Store at -20℃

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Remarks

NVP-BVU972, also known as BVN-972, is a selective and potent inhibitor of c-Met with IC50 of 14 nM. BVN-972 displays IC50 values more than 1000 nM in other kinases such as the most closely related kinase recepteur d'origine nantais (RON).

Related Products:

MGCD-265 analog; BMS777607; JNJ-38877605; Tivantinib; AMG-208; AMG-458; Golvatinib; SU11274; BMS-794833; PF-04217903; Crizotinib

References

[1]. Tiedt, Ralph, et al. A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients. Cancer Research (2011), 71(15), 5255-5264.

[2]. Shin JS, et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs. 2013 Oct 31.