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BMS-794833

BMS-794833 1174046-72-0
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Chemical Information
Product name:BMS-794833 Purity:98% min
CAS NO:1174046-72-0 Solubility:DMSO : ≥ 100 mg/mL (213.29 mM)
Molecular Formula:C23H15ClF2N4O3 Package:Package according to customer requirements
Molecular Weight:468.840 Storage:Store at -20℃
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Remarks

BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM. BMS-794833 also inhibits Ron (Met family), Axl (phylogenetically related Axl/Tyro3/Mer subfamily) and Flt-3 with IC50 values less than 3 nM. The compound was selective versus a panel of greater than 200 additional receptor tyrosine kinase (RTKs), non-RTKs and serine/threonine kinases based on biochemical or Ambit binding assays. Moreover, it inhibited the cell growth in GTL-16 gastric carcinomas with an IC50 of 39 nM . In vivo, BMS-794833 exhibited dose-dependent anti-tumor activity against multiple tumor types without overt toxicities at efficacious dose levels.

 

 

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References
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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