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Tivantinib

Tivantinib 905854-02-6
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Chemical Information
Product name:Tivantinib Purity:98% min
CAS NO:905854-02-6 Solubility:10 mM in DMSO
Molecular Formula:C23H19N3O2 Package:Protein Tyrosine Kinase/RTK
Molecular Weight:369.416 Storage:Store at -20℃
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Remarks

Tivantinib (ARQ-197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing consitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.

 

 

 

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