GNF-5837

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：GNF-5837	Purity：98% min
CAS NO：1033769-28-6	Solubility：DMSO : ≥ 32 mg/mL (59.76 mM)
Molecular Formula：C₂₈H₂₁F₄N₅O₂	Package：Package according to customer requirements
Molecular Weight：535.492	Storage：Store at -20℃

Quality control

Remarks

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of GNF-5837 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.

Trk receptor Inhibitors Related Products:

SP600125; Danusertib; GW441756; Altiratinib; Ropotrectinib; Larotrectinib sulfate; Entrectinib; ANA-12

References

[1]. Albaugh, P. et al. Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS MEDICINAL CHEMISTRY LETTERS, 2012; 3 (2): 140