SP600125

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Chemical Information

Product name：SP600125	Purity：98% min
CAS NO：129-56-6	Solubility：DMSO : ≥ 45 mg/mL (204.33 mM)
Molecular Formula：C₁₄H₈N₂O	Package：Package according to customer requirements
Molecular Weight：220.226	Storage：Store at -20℃

Quality control

Remarks

SP-600125 is a specific JNK inhibitor. SP600125 kills p53-deficient cells more efficiently than their p53-proficient counterparts, in vitro. Similar observations were obtained in vivo, in mice carrying p53-deficient and -proficient human xenografts.

Properties:

Appearance & Physical State: yellow

Density: 1.463 g/cm3

Boiling Point: 489.3ºC at 760 mmHg

Melting Point: 281-282ºC

Flash Point: 246.8ºC

Refractive Index: 1.799

Vapor Pressure: 1.01E-09mmHg at 25°C

Aurora Kinase Related Prodcuts:

Alisertib; Tozasertib; Danusertib; AT9283; Hesperadin; ENMD-2076; ENMD-2076 Tartrate; MK-5108; CYC-116; GSK-1070916A; CCT137690; XL228; SNS-314; SNS-314 mesylate; MK-8745

References

[1]. Bennett BL, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A, 2001, 98(24), 13681-13686.

[2]. Vaishnav D, et al. SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. Biochem Biophys Res Commun, 2003, 307(4), 855-860.