MK-8745

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：MK-8745	Purity：98% min
CAS NO：885325-71-3	Solubility：DMSO : ≥ 34 mg/mL (78.72 mM)
Molecular Formula：C₂₀H₁₉ClFN₅OS	Package：Package according to customer requirements
Molecular Weight：431.914	Storage：Store at -20℃

Quality control

Remarks

MK-8745 is a novel Aurora-A specific inhibitor. MK8745 induced apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK8745 resulted in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. p53-dependent apoptosis by MK8745 was further confirmed in HCT 116 p53(-/-) cells transfected with wild-type p53.

Aurora Kinase Related Prodcuts:

Alisertib; Tozasertib; SP600125; Danusertib; AT9283; Hesperadin; ENMD-2076; ENMD-2076 Tartrate; MK-5108; CYC-116; GSK-1070916A; CCT137690; XL228; SNS-314; SNS-314 mesylate

References

[1]. Jayasree S Nair et al. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent.

[2]. Aparajita Chowdhury et al. A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines. Leuk Lymphoma, 2012 Mar, 53(3):462-71.