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AT9283 896466-04-9
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Chemical Information
Product name:AT9283 Purity:98% min
CAS NO:896466-04-9 Solubility:DMSO : ≥ 100 mg/mL (262.17 mM)
Molecular Formula:C19H23N7O2 Package:Package according to customer requirements
Molecular Weight:381.432 Storage:Store at -20℃
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AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML.

Density: 1.45g/cm3
Refractive Index: 1.714

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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