AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML.
Properties:
Density: 1.45g/cm3
Refractive Index: 1.714
Aurora Kinase Related Prodcuts:
Alisertib; Tozasertib; SP600125; Danusertib; Hesperadin; ENMD-2076; ENMD-2076 Tartrate; MK-5108; CYC-116; GSK-1070916A; CCT137690; XL228; SNS-314; SNS-314 mesylate; MK-8745